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The TB-500 guideUnderstand. Check. Ask. Bring your questions

Check the claim

Find the record behind an answer

Start with the chapter note, then read the source for the question you are checking.

In the US, medicines are reviewed by the Food and Drug Administration, known as the FDA.

Choose the record for your question

For the substance and human evidence

The FDA review covers the short piece called TB-500. Check whether other research tested that piece or the whole thymosin beta-4 protein.

  • The FDA's TB-500 review found no published human study of the fragment and distinguishes it from thymosin beta-4.
  • For a study result, check the ingredient, how it was given, and the main aim.
  • For a claim of current research, ask for the full study record on ClinicalTrials.gov, a public list of studies. The studies chapter links to records there.

For the current status

Read the date and the type of document. A staff proposal, a committee's advice, and a final rule mean different things.

  • As of September 2026, TB-500 has no FDA approval. The group withdrew its request for TB-500 to become a pharmacy ingredient; this did not give permission to use it.
  • As of September 30, 2026, no official record of votes on the reviewed substances appeared on the FDA's committee meeting page.
  • Read a newer document for what it actually changes, rather than assuming it replaces everything before it.

For care checks

The record held by the relevant board is the place to check a licence.

  • State medical boards hold doctor licence and public discipline records, while state pharmacy boards hold pharmacy licence records.
  • Use the care-check chapter to reach the board directories.
  • Bring an unclear claim to the visit and ask for its source.

Notes for this chapter

  1. FDA · Review of the fragment and its evidence
  2. FDA · Ingredient requests and safety concerns
  3. FDA · Committee meeting record
  4. Medical boards · Public licence records
  5. FDA · Find a state pharmacy licence search